Adenosine 5'-monophosphate | 61-19-8

Adenosine 5'-monophosphate (AMP) ndi nucleotide yopangidwa ndi adenine, ribose, ndi gulu limodzi la phosphate.

Kapangidwe ka Mankhwala: AMP imachokera ku nucleoside adenosine, kumene adenine imagwirizanitsidwa ndi ribose, ndipo gulu lina la phosphate limamangiriridwa ku 5' carbon of ribose kupyolera mu mgwirizano wa phosphoester.

Udindo Wachilengedwe: AMP ndi gawo lofunikira la nucleic acid, lomwe limagwira ntchito ngati monomer popanga mamolekyu a RNA. Mu RNA, AMP imaphatikizidwa mu unyolo wa polima kudzera mu ma phosphodiester bond, ndikupanga msana wa RNA strand.

Mphamvu Metabolism: AMP imakhudzidwanso ndi metabolism yamphamvu yama cell. Amagwira ntchito ngati kalambulabwalo wa adenosine diphosphate (ADP) ndi adenosine triphosphate (ATP) kudzera muzochita za phosphorylation zomwe zimakhudzidwa ndi michere monga adenylate kinase. ATP, makamaka, ndiye chonyamulira champhamvu m'maselo, chomwe chimapereka mphamvu zama cell osiyanasiyana.

Metabolic Regulation: AMP imagwira ntchito pakuwongolera mphamvu zama cell. Ma cell a AMP amatha kusinthasintha potengera kusintha kwa kagayidwe kachakudya komanso zofuna zamphamvu. Miyezo yayikulu ya AMP yokhudzana ndi ATP imatha kuyambitsa njira zowona mphamvu zama cell, monga AMP-activated protein kinase (AMPK), yomwe imayang'anira kagayidwe kachakudya kuti isunge mphamvu ya homeostasis.

Gwero lazakudya: AMP imatha kupezeka kuchokera kuzakudya, makamaka muzakudya zokhala ndi ma nucleic acid, monga nyama, nsomba, ndi nyemba.

Pharmacological Applications: AMP ndi zotuluka zake zafufuzidwa kuti zitha kugwiritsidwa ntchito pachipatala. Mwachitsanzo, cAMP (cyclic AMP), yochokera ku AMP, imagwira ntchito ngati mesenjala wachiwiri panjira zotumizira ma sigino ndipo imayang'aniridwa ndi mankhwala osiyanasiyana ochizira matenda monga mphumu, matenda amtima, ndi kusalinganika kwa mahomoni.