Adenosine | 58-61-7

Adenosine, nucleoside yopangidwa ndi adenine ndi ribose, imakhala ndi ntchito zingapo zofunika pazamankhwala ndi physiology chifukwa cha momwe thupi limakhudzira machitidwe osiyanasiyana m'thupi.

Mankhwala a mtima:

Chida Chodziwiratu: Adenosine imagwiritsidwa ntchito ngati mankhwala osokoneza bongo panthawi ya mayesero a mtima, monga kujambula kwa myocardial perfusion. Imathandiza kuyesa matenda a mitsempha ya m'mitsempha mwa kupangitsa kuti mtima ukhale wa vasodilation, kutengera zotsatira za masewera olimbitsa thupi.

Chithandizo cha Supraventricular Tachycardia (SVT): Adenosine ndi mankhwala a mzere woyamba kuthetsa zigawo za SVT. Zimagwira ntchito pochepetsa kuyendetsa kudzera mu node ya atrioventricular, kusokoneza njira zobwereranso zomwe zimayambitsa SVT.

Neurology:

Kuwongolera Kugwira: Adenosine ndi anticonvulsant yokhazikika muubongo. Ma modulating adenosine receptors amatha kukhala ndi zotsatira za antiepileptic, ndipo adenosine-release agents akufufuzidwa ngati njira zothandizira khunyu.

Neuroprotection: Adenosine receptors amathandizira kuteteza ma neuron ku kuvulala kwa ischemic ndi kupsinjika kwa okosijeni. Kafukufuku amafufuza kuthekera kwa adenosine ngati neuroprotective wothandizira pa sitiroko ndi matenda a neurodegenerative monga Parkinson's ndi Alzheimer's.

Mankhwala Opumira:

Bronchodilation: Adenosine imakhala ngati bronchodilator ndipo imagwiritsidwa ntchito poyesa bronchoprovocation kuti azindikire mphumu. Zimayambitsa bronchoconstriction mwa anthu omwe ali ndi mphumu, zomwe zimathandiza kuzindikira kuopsa kwa airway.

Makhalidwe a Antiarrhythmic:

Adenosine akhoza kupondereza mitundu ina ya arrhythmias mwa modulating magetsi mu mtima, makamaka atria ndi atrioventricular mfundo. Theka lake lalifupi theka moyo malire zokhudza zonse zotsatira.

Chida Chofufuzira:

Adenosine ndi ma analogi ake chimagwiritsidwa ntchito kafukufuku kuphunzira udindo wa adenosine zolandilira zosiyanasiyana zokhudza thupi ndi pathological njira. Amathandizira kufotokozera ntchito za adenosine mu neurotransmission, kuyankha kwa chitetezo chamthupi, kutupa, komanso kuwongolera mtima.

Njira Zochiritsira Zomwe Zingachitike:

Mankhwala opangidwa ndi adenosine akufufuzidwa kuti azitha kuchiza matenda monga khansa, kuvulala kwa ischemic, kusamalira ululu, ndi matenda otupa. Adenosine receptor agonists ndi antagonists ndi ena mwa mankhwala omwe akuphunziridwa.