Flubendazole | 31430-15-6
Mafotokozedwe Akatundu:
Flubenzimidazole ndi mankhwala ophera tizilombo a benzimidazole omwe amatha kulepheretsa kuyamwa kwa nematode ndikuphatikiza ma intracellular microtubules.
Ikhoza kukhala yogwirizana kwambiri ndi tubulin (mapuloteni a dimer subunit a microtubules) ndi kulepheretsa ma microtubules kuchokera ku polymerizing mu maselo a mayamwidwe (ie mayamwidwe maselo a m'matumbo a nematodes). Ikhoza kutsimikiziridwa ndi kutha kwa (zabwino) cytoplasmic microtubules ndi kudzikundikira kwa secretory particles mu cytoplasm chifukwa cha kutsekedwa kotsekedwa.
Zotsatira zake, chophimba cha cell membrane chimakhala chochepa thupi, ndipo kuthekera kwa kugaya ndi kuyamwa zakudya kumachepa. Chifukwa cha kudzikundikira kwa zinthu zobisika (ma hydrolases ndi ma proteolytic enzymes), ma cell amakumana ndi lysis ndi kuwonongeka, zomwe zimapangitsa kufa kwa tiziromboti.
Ntchito:
Flubenzimidazole ndi mankhwala othamangitsa tizilombo omwe amatha kuthana ndi tizilombo toyambitsa matenda agalu, monga mphutsi za m'mimba, hookworms, ndi whipworms; Nthawi yomweyo, imathanso kuchiza matenda ambiri am'mimba mu nkhumba ndi nkhuku, monga Ascaris suum, Hyostrongylus rubidus, Oesophagostomum dentatum, Trichuris suis, Metastrongylus apri, etc.
Flubenzimidazole sangaphe akulu okha komanso mazira.
