Fludarabine | 21679-14-1

Fludarabine ndi mankhwala a chemotherapy omwe amagwiritsidwa ntchito makamaka pochiza mitundu ina ya khansa, makamaka hematological malignancies. Nazi mwachidule:

Njira Yogwirira Ntchito: Fludarabine ndi analogi ya nucleoside yomwe imasokoneza kaphatikizidwe ka DNA ndi RNA. Imalepheretsa DNA polymerase, DNA primase, ndi DNA ligase enzymes, zomwe zimayambitsa kusweka kwa DNA strand ndikuletsa njira zokonza DNA. Kusokonekera kwa kaphatikizidwe ka DNA kumapangitsa kuti apoptosis (ma cell kufa) m'maselo omwe amagawika mwachangu, kuphatikiza ma cell a khansa.

Fludarabine amagwiritsidwa ntchito pochiza matenda a lymphocytic leukemia (CLL), komanso matenda ena a hematological monga indolent non-Hodgkin lymphoma ndi mantle cell lymphoma. Itha kugwiritsidwanso ntchito nthawi zina za pachimake myeloid leukemia (AML).

Ulamuliro: Fludarabine nthawi zambiri imaperekedwa kudzera m'mitsempha (IV) m'malo azachipatala, ngakhale itha kuperekedwanso pakamwa nthawi zina. Mlingo ndi ndondomeko ya kayendetsedwe ka kayendetsedwe kake zimadalira khansa yomwe ikuchiritsidwa, komanso thanzi la wodwalayo komanso momwe akuyankhira chithandizo.

Zotsatira zoyipa: Zotsatira zoyipa za fludarabine zimaphatikizapo kuponderezedwa kwa mafupa (zomwe zimatsogolera ku neutropenia, kuchepa magazi, ndi thrombocytopenia), nseru, kusanza, kutsekula m'mimba, kutentha thupi, kutopa, komanso kuwonjezereka kwa matenda. Zitha kuyambitsanso zovuta zoyipa monga neurotoxicity, hepatotoxicity, komanso kawopsedwe ka m'mapapo nthawi zina.

Chenjezo: Fludarabine imatsutsana ndi odwala omwe ali ndi vuto lalikulu la mafupa kapena kuwonongeka kwaimpso. Iyenera kugwiritsidwa ntchito mosamala odwala omwe anali ndi matenda a chiwindi kapena impso omwe analipo kale, komanso amayi apakati kapena oyamwitsa chifukwa chotha kuvulaza mwana wosabadwayo kapena khanda.

Kugwiritsa Ntchito Mankhwala Osokoneza Bongo: Fludarabine ikhoza kuyanjana ndi mankhwala ena, makamaka omwe amakhudza fupa la mafupa kapena ntchito ya impso. Ndikofunika kuti opereka chithandizo chamankhwala awunikenso mndandanda wamankhwala omwe wodwalayo ali nawo ndikuwunika momwe angagwiritsire ntchito mankhwalawo.

Kuyang'anira: Kuwunika pafupipafupi kuchuluka kwa magazi ndi ntchito yaimpso ndikofunikira mukalandira chithandizo ndi fludarabine kuti muwone ngati pali zizindikiro za kuponderezedwa kwa mafupa kapena zovuta zina. Kusintha kwa mlingo kungakhale kofunikira potengera izi.