Huperzine A ｜120786-18-7

Huperzine A ndiwowonjezera chidziwitso chomwe chimalepheretsa ma enzymes omwe amasokoneza kuphunzira kwa neurotransmitter acetylcholine. Ndiwo gulu la cholinergic la mamolekyu omwe angathandize kuthana ndi kuchepa kwa chidziwitso mwa okalamba.

Huperzine A ndi gulu lochokera ku banja la huperzine. Imatchedwa acetylcholinesterase inhibitor, kutanthauza kuti imalepheretsa enzyme kuti isaswe acetylcholine, zomwe zimapangitsa kuti acetylcholine achuluke.

Acetylcholine imatchedwa neurotransmitter yophunzirira ndipo imakhudzidwanso ndi kukangana kwa minofu.

Huperzine A ikuwoneka kuti ndi yotetezeka kwambiri. Kawopsedwe ndi maphunziro a anthu kuchokera ku maphunziro a nyama sanawonetse zotsatira zake pamilingo yowonjezereka yowonjezereka. Huperzine A ikugwiritsidwanso ntchito m'mayesero oyambirira pofuna kupewa matenda a Alzheimer's.

Huperzine A imapezeka mu cerebrospinal fluid ndipo imadutsa mosavuta chotchinga cha magazi ndi ubongo.

Huperzine A amadziwika bwino ngati acetylcholinesterase inhibitor. Makamaka, imalepheretsa G4 subtype ya acetylcholinesterase, yomwe imapezeka mu ubongo wa mammalian. Ndiwothandiza kwambiri kapena mofananamo motsutsana ndi zoletsa zina za acetylcholinesterase, monga tacillin kapena rivastatin. Monga inhibitor, imakhala ndi kuyanjana kwakukulu kwa acetylcholinesterase. Panthawi imodzimodziyo, imakhala ndi nthawi yowonongeka pang'onopang'ono, yomwe imapangitsa kuti theka la moyo likhale lalitali kwambiri.

Kuphatikiza pa kuletsa acetylcholinesterase, imathanso kuwonedwa ngati neuroprotective motsutsana ndi glutamate, beta amyloid pigmentation, ndi H2O2-induced toxicity.

Huperzine A imatha kulimbikitsa kuchuluka kwa ma cell a hippocampal neural stem cell (NSCs). Zikuwoneka kuti zimalimbikitsa kukula kwa mitsempha pamiyeso yokhudzana ndi biorelated.