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Magnolia officinalis extract (dzina la Chingerezi: Magnolia officinalis PE ), zosakaniza zogwira ntchito: ndi magnolol, magnolol, magnolol total phenol. Gwero la Botanical: Zomwe zimagwira ntchito mu antibacterial mu khungwa la Magnolia officinalis Rehder et Wilson, mankhwala achi China.

Izi ndi zoyera za ufa wa crystal. Kusungunuka mu benzene, ether, chloroform, acetone, osasungunuka m'madzi, kusungunuka mosavuta mu njira ya alkali yosungunuka kuti mupeze mchere wa sodium. Gulu la phenolic hydroxyl ndi losavuta kukhala ndi okosijeni, pomwe gulu la allyl ndilosavuta kuchitapo kanthu.

Ili ndi mphamvu yapadera, yokhalitsa minofu yopumula komanso mphamvu ya antibacterial, yomwe imatha kuletsa kuphatikizika kwa mapulateleti.

Zachipatala, zimagwiritsa ntchito ngati antibacterial ndi antifungal mankhwala. Chogulitsachi chiyenera kusindikizidwa kutali ndi kuwala ndikusungidwa pamalo owuma, ozizira komanso mpweya wabwino.

Kuchita bwino ndi udindo wa Magnolia Cortex Extract 2% Honokiol: 

Anti-kutupa

Muzochitika zotupa, cell membrane phospholipids imatulutsa arachidonic acid (AA) pansi pa phospholipase A2.

Pali njira ziwiri za kagayidwe kachakudya za AA, imodzi ndiyo kupanga prostaglandins ndi thromboxanes pogwiritsa ntchito cyclooxygenase (COX), ndipo ina ndiyo kupanga prostaglandins ndi thromboxanes pogwiritsa ntchito cyclooxygenase (COX). Zochita za lipoxygenase (LO) zimapanga leukotrienes (LT).

Honokiol pamagulu apamwamba amalepheretsa ntchito ya COX m'maselo osokonezeka, ndikuletsa njira ya LO metabolic. Chifukwa chake, honokiol ndi inhibitor iwiri ya COX ndi LO.

Mphamvu yotsutsa-kutupa ya honokiol ikhoza kukhala yokhudzana ndi kuletsa kwake njira ziwiri za metabolic za AA. Komanso, honokiol akhoza ziletsa amasulidwe lysosomal michere, kuchepetsa permeability wa makoma capillary kuzungulira malo kutupa, ndi ziletsa leukocyte kusamuka ndi fibrous minofu kuchulukana.

Antioxidant

Magnolol ndi Honokiol ali ndi zotsatira zowononga zowonongeka, zomwe zimatha kuwononga ma parahydroxyl radicals ndi hydrogen peroxide.

Nthawi yomweyo, imatha kuteteza ntchito ya michere yopumira ya mitochondrial motsutsana ndi kupsinjika kwa peroxidative ya NADPH, kutsutsa okosijeni ya hemolysis ya maselo ofiira amwazi, ndikuletsa lipid peroxidation.

Maphunziro angapo a in vitro ndi mu vivo adawunika ntchito ya antioxidant ya Magnolia officinalis extract, yomwe imakhala yamphamvu nthawi 1000 kuposa alpha-tocopherol.