Tacrolimus | 104987-11-3

Tacrolimus, yomwe imadziwikanso ndi dzina lake la malonda Prograf pakati pa ena, ndi mankhwala amphamvu oletsa chitetezo chathupi omwe amagwiritsidwa ntchito makamaka pakuika ziwalo kuti asakanidwe.

Njira Yogwirira Ntchito: Tacrolimus amagwira ntchito poletsa calcineurin, puloteni phosphatase yomwe imagwira ntchito yofunika kwambiri poyambitsa ma T-lymphocyte, omwe ndi maselo a chitetezo chamthupi omwe amakhudzidwa ndi kukanidwa kwa graft. Poletsa calcineurin, tacrolimus imalepheretsa kupanga ma cytokines oyambitsa kutupa ndikuletsa kuyambitsa kwa T-maselo, potero kulepheretsa chitetezo cha mthupi kulimbana ndi chiwalo chomwe chasinthidwa.

Tacrolimus akusonyeza kwa prophylaxis wa limba kukanidwa odwala kulandira allogeneic chiwindi, impso, kapena kumuika mtima. Nthawi zambiri amagwiritsidwa ntchito limodzi ndi ma immunosuppressive agents monga corticosteroids ndi mycophenolate mofetil.

Ulamuliro: Tacrolimus nthawi zambiri imaperekedwa pakamwa ngati makapisozi kapena yankho lapakamwa. Atha kuperekedwanso kudzera m'mitsempha nthawi zina zachipatala, monga nthawi yomwe yangotha ​​kumene kumuika.

Kuyang'anira: Chifukwa chakuchepa kwake kwa machiritso komanso kusiyanasiyana kwa mayamwidwe, tacrolimus imafuna kuyang'anira mosamala kuchuluka kwa magazi kuti zitsimikizire kuchiritsa kwake ndikuchepetsa chiopsezo cha kawopsedwe. Kuyang'anira mankhwala ochizira kumaphatikizapo kuyeza pafupipafupi kwa tacrolimus m'magazi komanso kusintha kwa mlingo kutengera milingo iyi.

Zotsatira zoyipa: Zotsatira zoyipa za tacrolimus zimaphatikizapo nephrotoxicity, neurotoxicity, kuthamanga kwa magazi, hyperglycemia, kusokonezeka kwa m'mimba, komanso kutengeka kwambiri ndi matenda. Kugwiritsa ntchito tacrolimus kwa nthawi yayitali kungapangitsenso chiopsezo chokhala ndi matenda ena, makamaka khansa yapakhungu ndi lymphoma.

Tacrolimus ndi zimapukusidwa makamaka ndi cytochrome P450 puloteni dongosolo, makamaka CYP3A4 ndi CYP3A5. Chifukwa chake, mankhwala omwe amapangitsa kapena kuletsa ma enzymes awa amatha kukhudza kuchuluka kwa tacrolimus m'thupi, zomwe zingayambitse kulephera kwamankhwala kapena kawopsedwe.

Kuganizira Kwapadera: Kuyeza kwa Tacrolimus kumafuna munthu payekha payekha malinga ndi zaka za wodwala, kulemera kwa thupi, kugwira ntchito kwa aimpso, mankhwala osakanikirana, ndi kupezeka kwa co-morbidities. Kuyang'anira mosamala komanso kutsata pafupipafupi ndi othandizira azachipatala ndikofunikira kuti muchepetse chithandizo ndikuchepetsa zotsatira zoyipa.