Uridine | 58-96-8

Uridine ndi pyrimidine nucleoside yomwe imakhala ngati maziko opangira RNA (ribonucleic acid), imodzi mwa mitundu iwiri ikuluikulu ya nucleic acid yofunika kusungirako ndi kufalitsa chidziwitso cha majini m'maselo.

Kapangidwe ka Mankhwala: Uridine imakhala ndi pyrimidine base uracil yomwe imamangiriridwa ku ribose ya shuga ya carbon-5 kudzera pa β-N1-glycosidic bond.

Udindo Wachilengedwe:

RNA Building Block: Uridine ndi gawo lofunikira la RNA, pomwe limapanga msana wa mamolekyu a RNA pamodzi ndi ma nucleosides ena monga adenosine, guanosine, ndi cytidine.

Messenger RNA (mRNA): Mu mRNA, zotsalira za uridine zimasunga chidziwitso cha majini panthawi yolemba, kunyamula malangizo kuchokera ku DNA kupita kumakina opangira mapuloteni muselo.

Kusamutsa RNA (tRNA): Uridine imakhalanso ndi ma molekyulu a intRNA, pomwe imagwira nawo ntchito yomasulira pozindikira ma codon enieni ndikupereka ma amino acid ofanana ku ribosome.

Metabolism: Uridine imatha kupangidwa ndi novo mkati mwa maselo kapena kutengedwa kuchokera ku zakudya. Amapangidwa kudzera mu kutembenuka kwa enzymatic kwa orotidine monophosphate (OMP) kapena uridine monophosphate (UMP) mu njira ya pyrimidine biosynthesis.

Kufunika Kwathupi:

Neurotransmitter Precursor: Uridine imagwira ntchito muubongo ndi chitukuko. Ndi kalambulabwalo wa kaphatikizidwe ka phospholipids muubongo, kuphatikiza phosphatidylcholine, yomwe ndi yofunikira paumphumphu wa minyewa ya neuronal ndi chizindikiro cha neurotransmitter.

Zotsatira za Neuroprotective: Uridine adaphunziridwa chifukwa cha mphamvu zake zoteteza mitsempha komanso kuthekera kwake kopititsa patsogolo ntchito ya synaptic ndi neuronal plasticity.

Mphamvu Zochizira:

Uridine ndi zotumphukira zake adafufuzidwa kuti azitha kuchiza matenda amisala, kuphatikiza matenda a Alzheimer's ndi kusokonezeka kwamalingaliro.

Uridine supplementation yafufuzidwa ngati njira yothandizira chidziwitso ndikuchepetsa zizindikiro zomwe zimagwirizanitsidwa ndi matenda a neurodegenerative.

Zakudya: Uridine amapezeka mwachibadwa muzakudya zosiyanasiyana, kuphatikizapo nyama, nsomba, masamba, ndi mkaka.