Chipatso cha Cnidium | 484-12-8

Mafotokozedwe Akatundu:

Cnidium, yomwe imadziwikanso kuti fennel yakutchire, mbewu ya karoti yakuthengo, mpunga wa njoka, mgoza wa njoka, ndi zina zambiri, ndi chipatso chouma cha Cnidium monnieri, chomera cha Umbelliferae Apiaceae.

Cnidium ndi zitsamba zapachaka. Imakonda malo ofunda ndi achinyezi, siwopa kuzizira kwambiri ndi chilala, ndipo imatha kusinthasintha. Imagawidwa ku East China, Central ndi South China ndi madera ena.

Kuchita bwino ndi udindo wa Cnidium Fruit Extract: 

Osthole ali ndi inhibitory zotsatira pa Staphylococcus aureus, Pseudomonas aeruginosa ndi Escherichia coli, ndipo amathanso kuchepetsa pathogenicity ya Staphylococcus aureus zotsalira tizilombo.

Itha kugwiritsidwa ntchito molumikizana ndi matrine, etc. pochiza trichomonas vaginitis, eczema, psoriasis, etc.

Anti-inflammatory: 

Osthole imalepheretsa Staphylococcus aureus ndipo imakhala ndi zotsatira zabwino pa kutupa kwa bakiteriya. Osthole pamodzi ndi baicalin akhoza synergistically kuchiza chibayo chifukwa Staphylococcus aureus.

Anti-cancer:

Osthole imatha kuletsa kukula kwa chotupa mumitundu ya khansa ya chiwindi cha mbewa, kuyambitsa apoptosis ya maselo a khansa ya chiwindi kudzera muzolinga zingapo ndi njira zingapo, ndikuwonjezera kuyankha kwa anti-chotupa kwa mbewa za khansa ya chiwindi; osthole amathanso kupha maselo a khansa ya m'mphuno, maselo a khansa ya m'mapapo ndi maselo a khansa ya khomo lachiberekero ali ndi zotsatira zolepheretsa kukula kwa maselo osiyanasiyana otupa. Itha kugwiritsidwa ntchito pothandizira anti-cancer.

Anti-osteoporosis:

Osthole amatha kulimbikitsa kwambiri kufalikira ndi kusiyanitsa kwa mafupa a mesenchymal stem cell ndi osteoblasts, ndipo panthawi imodzimodziyo amawonjezera kwambiri mawu a osteocalcin ndi alkaline phosphatase, potero amalimbikitsa mapangidwe a mafupa, kuwonjezera mafupa a mafupa ndi mphamvu ya mafupa. Osthole amalimbikitsa kufalikira ndi kusiyanitsa kwa osteoblasts pokhudzana ndi ndende, ndipo ndende yabwino kwambiri ili pakati pa 5 * 10-5M-5 * 10-4M.

Komanso, kuphatikiza osthole ndi puerarin akhoza synergistically kuchiza fupa dysplasia ndi osteoporosis.

Zotsatira pa dongosolo la endocrine:

Osthole akhoza kulimbikitsa kaphatikizidwe ndi katulutsidwe ka androgen m'maselo a Leydig mwa kuwongolera kulembedwa kwa jini kwa ma enzymes okhudzana ndi ma cell membrane ndi zolandilira zokhudzana ndi cytoplasm mu njira ya androgen kaphatikizidwe m'maselo a Leydig mu mbewa;

Ikhoza kuonjezera zomwe zili mu testosterone, follicle-stimulating hormone ndi luteinizing hormone mu seramu, ndipo imakhala ndi zotsatira za androgen ndi gonadotropin; ndi osthole pa 40-80μg/mL amatha kuthetsa kupsinjika kwa okosijeni komwe kumachitika ndi H2O2 mu minofu ya ovarian. Kulimbikitsa kuvulala, kuteteza kugwira ntchito kwa minofu ya ovarian, ndikuwonjezera mphamvu ya antioxidant ya minofu ya ovarian.

Zochepa za osthole zingagwiritsidwe ntchito ngati mankhwala ophera tizilombo, chitetezo chosungira mbewu, ndi zina zotero. ali ophatikizana kwambiri masamba downy mildew ndi nsabwe za m'masamba.

Poyerekeza ndi mankhwala ena ophera tizilombo, osthole ali ndi ubwino wochita bwino kwambiri komanso kawopsedwe wochepa.